Amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig’s disease, is a progressive neurodegenerative disorder that affects the motor neurons in the brain and spinal cord. This condition gradually robs individuals of their ability to control muscle movements, ultimately leading to paralysis and, in many cases, respiratory failure. It is a rare disease that primarily affects the motor neurons responsible for controlling voluntary muscles. These neurons deteriorate over time, leading to muscle weakness, twitching, and, eventually, paralysis. ALS can vary widely in its progression and symptoms, making early detection vital for treatment and management. Early diagnosis is crucial for managing ALS effectively. This article explores the subtle but significant early signs and symptoms of ALS. Mentioned below are the early signs and symptoms of ALS: Muscle weakness One of the earliest and most prominent signs of ALS is muscle weakness. Initially, individuals might notice difficulty performing simple tasks requiring muscle strength, such as lifting objects, climbing stairs, or getting up from a chair. Weakness often starts in the limbs, typically in one arm or leg, and then spreads to other body parts. Muscle twitching (fasciculations) Muscle twitching or fasciculations can be an early symptom of ALS. These involuntary, spontaneous muscle contractions may occur randomly in various body parts.