Prurigo nodularis is a relatively rare but highly distressing skin condition that can severely impact one’s quality of life. Characterized by the development of itchy nodules on the skin, it can cause significant discomfort and affect one’s mental health. The condition can also worsen due to existing health issues. Understanding the causes, signs and symptoms, available treatments, and preventive measures of Prurigo Nodularis (PN) is crucial for timely intervention and better management. What is prurigo nodularis and which parts of the body does it affect? PN is a chronic inflammatory skin disorder characterized by the development of itchy nodules on the skin. It occurs when one engages in persistent scratching over an extended period. The nodules can vary in size, from a few millimeters to centimeters. They may be firm to touch, look like domes, and may be reddish-brown or brownish-black in color. PN can appear anywhere on the skin that one repeatedly scratches or rubs, but the most commonly affected areas include the legs, arms, lower and upper back, abdomen, and buttocks. 8 common signs and symptoms of prurigo nodularis While the symptoms can vary from person to person, the following are common signs and symptoms associated with PN: